铅对作业女工子代神经行为的影响

The effect of lead on the neurobehavioral function of descendents of female workers

目的 评价铅对其作业女工子代神经行为的影响。方法 对某冶炼厂职工子弟学校学生的母亲孕前至调查时从事铅作业的 94名 1～ 4年级小学生 ( 6～ 10岁 )作为接触组和无铅污染的农村小学 94名学生作对照 ,其年龄、性别、年级、家庭情况两组基本相同。用原子吸收光谱测定血铅 ;用ZPP 2 0 0 0荧光仪测定锌卟啉 ;用WHO推荐的神经行为核心测试组合 (NCTB)测定神经行为功能 ;用高压液相 ,134 0型电化学仪测定尿中HVA、VMA ;所有数据用SPSS软件作t检验。结果 血铅、血锌卟啉、血红蛋白、红细胞总数和尿中HVA及VMA等指标两组有非常显著的差别 (P <0 0 1)。行为功能数字跨度 (顺序 )得分 ,接触组显著低于对照组 (P <0 0 5) ,简单反应时最快值、数字跨度总和及数字跨度 (倒序 )得分接触组非常显著低于对照组 (P <0 0 1)。

Objective To evaluate the effect of lead on the neurobehavioral function of descendents of female workers.Methods 94 pupils (6～10 years old) from a primary school affiliated to a smeltery, whose mothers had been working with lead before pregnancy were selected as exposed group. Some other pupils in another countryside primary school were selected as control group. The age, sex, class and family condition of both groups were similar. Blood lead were detected by atomic absorption spectrophotometer; ZPP were detected by ZPP 2000 fluorometer neurobehavioral functions were evaluated by NCTB recommended by WHO; and urinary HVA, VMA were detected by high performance liquid chromatography. Data collected were analyzed by SPSS software in microcomputer for analaysis of variance and t test.Results Blood lead, blood ZPP, Hb, red blood cell count and HVA, VMA in urine of both groups showed significant difference ( P <0 01). The fastest value of simple reaction time, total value of digit span and the score of digit span (digit backward) in exposed group were much lower than those of the control group ( P <0.01).Conclusion Lead might be harmful to the neurobehavioral function of descendent of women workers.