地诺前列酮栓内置阴道后穹隆与催产素静脉滴注用于足月妊娠引产的临床对照研究

Clinical Controlled Study of Dinoprostone Suppositories Placed in Posterior Vaginal Fornix and Intravenous Drip of Oxytocin Used in Induced Labor of Full-Term Pregnancy

目的研究地诺前列酮栓(欣普贝生)内置阴道后穹隆与催产素静脉滴注用于足月妊娠引产的临床效果。方法选择足月妊娠引产患者78例,随机分为给予欣普贝生内置阴道后穹隆的观察组(39例)与应用催产素静脉滴注的对照组(39例),观察产妇和新生儿情况、负面情绪以及生活质量。结果与对照组比较,观察组临产时间、总产程、产后出血量、汉密尔顿抑郁量表(HAMA)评分、汉密尔顿焦虑量表(HAMD)评分均明显降低,卡氏行为状态评分表(KPS)评分、纽芬兰纪念大学幸福度量表(MUNSH)评分、自我护理能力测定量表(ESCA)评分以及总体生活质量评分均明显升高(P<0.05),而新生儿的体重、出生后1 min Apgar评分、出生后5 min Apgar评分均无明显差异(P>0.05)。结论地诺前列酮栓内置阴道后穹隆能改善产妇状态、缓解负面情绪、提高生活质量,具有积极的临床价值。

Objective To study the clinical effects of Dinoprostone Suppositories placed in posterior vaginal fornix and intravenous drip of oxytocin used in induced labor of full- term pregnancy. Methods 78 cases of induction of full- term pregnancy were collected and randomly divided into the observation group（39 cases） given Dinoprostone Suppositories placed in posterior vaginal fornix and the con- trol group（39 cases） given intravenous drip of oxytocin. Then the maternal and neonatal conditions,negative mood and quality of life were observed. Results Compared with the control group, the parturient time, total duration of labor, postpartum hemorrhage volume, HAMA scores and HAMD scores in the observation group were significantly decreased;KPS scores,MUNSH scores, ESCA scores and overall quality of life scores were significantly increased（P 〈 0.05）.But the neonatal birth weight,Apgar scores at postnatal 1,5 min had no significant differences between the two groups（P 〉 0.05）. Conclusion Dinoprostone Suppositories placed in posterior vaginal fornix can improve the maternal condition ,relieve the negative mood and increase the quality of life with positive clinical value.