福多司坦联合小剂量吸入性激素治疗支气管哮喘的临床研究

Clinical research of fudosteine combined with low dose of inhaled corticosteroid in the treatment of asthma

目的观察福多司坦联合小剂量吸入性糖皮质激素治疗轻中度哮喘的临床效果。方法将40例哮喘患者随机分为两组,实验组给与福多司坦联合小剂量二丙酸倍氯米松气雾剂,对照组给予大剂量二丙酸倍氯米松气雾剂。治疗前后评价PEFRv、FEVl%及不良反应。同时检测治疗前后诱导痰上清中IL-8含量的变化。结果福多司坦联合小剂量吸入性激素治疗轻、中度哮喘可显著降低PEFRv及提高FEVl%(P<0.05),两组间PEFRv改善百分比和FEVl%改善百分比均无明显统计学差异(P>0.05)。两组均可明显降低哮喘患者的诱导痰上清中IL-8的水平。结论小剂量吸入性激素联合福多司坦和大剂量吸入性激素对治疗轻中度哮喘的疗效相当。

Objective To observe the clinical curative effect of fudosteine combined with low dose of inhaled beclomethasone dipropionate（BDP） in the treatment of patients with moderate bronchial asthma.Methods 40 patients with moderate asthma were randomly divided into the treatment group and the control group.The control group was received inhaled BDP（500 ug / d）,and the treatment group was treated with fudosteine and low dose of inhaled BDP（250 ug / d）.Before and after the treatment,the peak expiratory flow rate variation（PEFRv）,forced expiratory volume in one second expressed as percentages of predicted normal values（FEVl%） and adverse reactions were compared between the two groups.Additionally,the level of IL-8 in sputum supernatant was also detected before and after the treatment.Results After the treatment,PEFRv decreased significantly and FEV1% increased significantly in the two groups（P〈0.05）,but there was no significant difference between the two groups（P〉0.05）.The level of IL-8 in sputum supernatant decreased greatly in the two groups after the treatment.Conclusion Fudosteine combined with low dose of inhaled BDP has the similar curative effect with high dose of inhaled BDP in the treatment of patients with moderate asthma.