肺表面活性物质联合气道正压呼吸治疗重症胎粪吸入综合征的临床疗效

Clinical curative effect of PS and NCPAS in the treatment of severe MAS

目的研究肺表面活性物质联合鼻塞式持续气道正压呼吸治疗重症胎粪吸入综合征的临床疗效。方法选择胎粪吸入综合征患儿作为研究对象,随机分为给予肺表面活性物质联合鼻塞式持续气道正压呼吸治疗的观察组和气管插管呼吸机辅助呼吸的对照组,观察呼吸功能、心功能以及神经功能。结果观察组患儿呼吸恢复平稳的时间、辅助呼吸的时间、X线征象消失的时间、舒张压、收缩压、舒张晚期充盈峰速度、意识恢复时间、肌张力恢复时间和吸吮反射恢复时间均明显低于对照组,动脉血氧分压、血氧饱和度、舒张早期充盈峰速度、E/A比值、神经行为评分均明显高于对照组。结论肺表面活性物质联合鼻塞式持续气道正压呼吸治疗能够有效改善呼吸功能。

Objective To study the clinical curative effect of PS and NCPAS in the treatment of severe MAS. Methods Infants with MAS were collected and randomly divided into the observation group and the control group. The observation group was given PS and NCPAS, and the control group was given endotracheal intubation assisted respiration. Then respiratory function, cardiac function and nerve function were observed. Results Respiratory recovery time, assisted respiration time, X-ray signs disappeared time, DBP, SBP, E peaks, consciousness recovery time, muscle tension recovery time and the sucking reflex recovery time were obviously lower in the observa- tion group than in the control group. SpO2, Apeak, ratio of E/A, neurobehavioral score were significantly higher in the observation group than in the control group. Conclusion PS and NCPAS have an active clinical value because it can effectively improve respiratory function of infants with MAS.