念珠菌ERG11基因耐药机制研究进展

Resistant mechanisms of ERGll gene of Candida

近年来，随着医疗技术与经济的发展，侵袭性真菌感染尤其是念珠菌感染病例持续增高。由于唑类药物的广泛应用，临床念珠菌耐药菌株不断出现，使得对耐药机制的深入研究迫在眉睫。在念珠菌对唑类药物的耐药机制中，麦角甾醇合成通路上ERG11基因的突变和高表达被视为念珠菌最重要的耐药机制之一，而ERG11基因突变和高表达可能是多种机制共同作用的结果。

Invasive fungal infections, especially candida spp infection, are increasing with the development of medical technology and economy in recent years. Azoles have many advantages in treating fungal infections. More and more resistance strains appear in clinical treatment because of the widely use of azoles. Therefore, research of the molecular mechanisms involving in azoles resistance is a serious imminent issue. ERG11 is a key enzyme in the ergosterol synthesis pathway of candida spp. Point mutations and over-express in ERG11 are deemed as one of the most important mechanisms of azoles resistance. The aim of this study is to systematically review the resistant mechanisms of ERG11 gene of candida to azoles.