世界食管癌高发区与煤矿分布——氮循环假说的五大环境因素之一

High-incidence areas of EC and coal mine distribution all over the world-one of the five environmental factors of hypothesis of nitrogen cycle

目的研究世界食管癌高发区与"食管癌氮循环假说"五大环境因素之一的世界煤矿资源分布关系。方法收集世界范围煤矿产区与世界食管癌高发区资料,进行比对。结果世界食管癌高发区约70.00%存在煤矿分布现象。结合煤矿矿井水发现二级胺结果,支持氮循环N-亚硝基化合物前体物病因假说。结论世界食管癌高发区与煤矿分布关系与"氮循环假说"相吻合,即食管癌高发区大部分有煤炭分布,但有煤炭分布的并非都是食管癌高发区,为该假说提供重要佐证。

objective To study the relationship of high-incidence areas of esophageal cancer and coal resources distribution,which is one of the five environmental factors oF＂Hypothesis of EC nitrogen cycle＂,Methods Collected and compared the world coal mining regions and the high-incidence areas of EC data. Results About 70.00 % high-incidence area of EC has coal distribution,all over the world.as secondary amine was found in coal mine water, support the etiological hypothesis of nitrogen cycle N-nitroso compound preeursr. Conclu- sion High-incidence areas of EC and coal distribution relationship in conformity with the ＂Hypothesis of nitrogen cycle ＂.Most of high-incidence areas of EC have coal distribution,but not the entire coal mining regionsis high-incidence of EC ,which provided an iportant evidence for this Hypothesis.