PCT在胎膜早破新生儿感染早期诊断中的临床意义

The clinical significance of PCT in early diagnosis of neonatal infection with premature rupture of membranes

目的探讨降钙素原(PCT)在胎膜早破新生儿感染早期诊断中的临床意义。方法对2011年1月～12月我科收治的89例胎膜早破新生儿进行回顾性分析,分为败血症组(n=17)、局部感染组(n=38)与非感染组(n=34),比较、分析不同组间的PCT、hsCRP。结果 PCT阳性率:败血症组(94.12%)>局部感染组(60.52%)>非感染组(8.82%),组间比较,P均<0.01。以0.5ng/ml为临界值,PCT诊断胎膜早破新生儿感染的敏感度为90.53%,特异度为91.17%,明显高于hsCRP的敏感度和特异度。结论 PCT对胎膜早破新生儿感染早期诊断具有较高的敏感度和特异度,感染的严重程度与血清PCT水平呈正相关。

Objective To explore the clinical significance of Pro ealeitonin （PCT） in early diagnosis of neonatal infection with premature rupture of membranes. Methods Retrospectivly analyzed 89 cases newborn infants with premature rupture of membranes from January 2011 - December, break them into septicemia group （ n = 17 ） ,local infection group （ n = 38 ） and non-infected group （n = 34） , compared and analyzed the PCT and hsCRP. Results The positive rates of PCT： septicemia group （94. 12% ） 〉 local infections group（60. 52% ） 〉 non-infectious group（8. 82% ） ,P〈0. 01. Prompting that the severity of the infection and serum level of PCT is positive correlation. A threshold of 0. 5ng/ml, the sensitivity and specificity of PCT respectively are 90. 53% and 91.17% in neonatal infection with premature rupture of membranes, significantly higher than the hsCRP. Conclusion PCT has a higher degree of sensitivity and specificity in early diagnosis of neonatal infection with premature rupture of membranes.