血清ICAM-1和IL-6水平与肾功能损害的相关性研究

The Correlation between Serum ICAM-1 and IL-6 Levels and the Degree of Renal Function Injury

目的:探讨血清细胞间粘附分子-1和白细胞介素-6表达与肾功能损害的相关性,用以评价血清ICAM-1和IL-6浓度检测用于评价肾功能损伤中的临床价值。方法:选择2011年8月-2012年7月来本院接受肾功能损伤检查的48例患者为研究对象。采用ELISA检测血清ICAM-1和IL-6浓度,采用半自动生化分析仪检测血清肌酐浓度并计算肾小球滤过率(eGFR)值。比较eGFR≥90组和eGFR<90组血清ICAM-1和IL-6浓度,并分析血清ICAM-1和IL-6浓度与eGFR的相关性。结果:eGFR<90组(肾功能损伤组)血清ICAM-1和IL-6浓度均显著高于eGFR≥90组(肾功能正常组)(P<0.05)。血清ICAM-1和IL-6浓度与eGFR呈显著地负相关性(r=-0.9283,P=0.013;r=-0.9369,P=0.001)。结论:血清ICAM-1和IL-6可能与肾功能损伤有关,且其浓度检测具有评价肾功能异常的潜在临床价值。

Objective： To investigate correlation of serum Intercellular adhesion molecule-1 and Interleukin-6 levels with renal injury, to reveal the clinical value of serum ICAM-1 and IL -6 concentration detection for evaluation of renal function injury.Method： 48 subjects were collected, who received renal function injury evaluation from August 2011 to July 2012. ELISA was performed to detect serum ICAM-1 and IL -6 concentration, and semi automatic biochemical analyzer was used to measure serum creatinine concentration, which was used for calculation of glomerular filtration rate （ eGFR ） value. Compared serum ICAM-1 and IL -6 concentrations of subjects with eGFR ~ 90 and eGFR 〈 90 , and analyzed the correlation betwecn serum ICAM-1 and IL -6 concentrations and eGFR value.Result： Serum ICAM-1 and interleukin -6 concentrations of eGFR 〈 90 group （ renal injury group ） were significantly higher than those of eGFR ≥ 90 group （ normal renl function group ） （ P〈0.05 ） .Serum ICAM-1 and IL -6 concentration and eGFR value of patients with eGFR 〈 90 were significantly negative correlation （ r=-0.9283, P=0.013; r=-0.9369, P=0.001 ） .Conclusion： The serum ICAM-I and interleukin -6 levels may correlate with the renal function injury development, and its concentration detection may have potential value for evaluating the degree of renal function injury.