摘要
溶酶体的完整性对维持细胞正常的代谢非常重要。溶酶体降解含铁的物质会使其内存在大量低质量铁。这些铁主要以还原型Fe(Ⅱ)形式存在并能诱导芬顿反应的发生,导致溶酶体膜完整性破坏。溶酶体膜透性增加会使一系列水解酶和还原铁进入胞浆进而诱导细胞损伤或死亡。此外,自噬在溶酶体铁代谢中也起着至关重要的作用。溶酶体铁处理的异常在一系列肾脏疾病中发挥着重要作用。
The lysosomal compartment is essential for a variety of cellular functions. Degradation of iron-containing macromolecules results in a large amount of low mass iron which exists in redox-active Fe （ II ） form in lysosomes. Fe （ II ） is known to catalyze Fenton reactions that may jeopardize lysosomal membrane integrity during oxidative stress. This results in the release of hydrolases and redox-active iron into the cytosol with ensuing damage or cell death. Besides, autophagy act as a crucial role in iron metabolism. Adversely affecting lysosomal iron handling can contribute to a variety of kidney diseases.
出处
《中国医学创新》
CAS
2013年第16期156-160,共5页
Medical Innovation of China
关键词
溶酶体
自噬
铁代谢
肾损伤
Lysosome
Autophagy
Iron metabolism
Kidney injury
