摘要
目的:评价以舒必利片为基础的FD综合治疗疗效。方法:选取2009年5月-2011年5月华北石油二部医院治疗的符合罗马Ⅲ标准的212例FD患者,随机分为两组,治疗组:根据病情常规给予莫沙必利片、兰索拉唑片等药物治疗,幽门螺杆菌病阳性者给予根除幽门螺杆菌治疗。对照组:在治疗组基础上加用舒必利片50mg/次,3次/d,饭前口服,连续治疗4周后停药,停药后当日及半年后评价疗效2次;分别记录治疗前后上腹痛、上腹饱胀、上腹胀感、嗳气、恶心、呕吐等症状,观察评分变化情况,综合评价治疗疗效。结果:212例FD患者能够完成治疗及半年后随访到180例,治疗组82例,有效率50.00%,对照组98例,有效率78.57%。结论:功能性消化不良患者在对症治疗基础上加用舒必利可使大多数FD患者的症状改善,明显提高疗效,并且停药后可使患者保持更长的缓解率。
Objective: To evaluate the efficacy of sulpiride in the treatment of functional dyspepsia.Methods: 212 patients with FD (Rome Ⅲ criteria) were enrolled in this study between 2009.05-2011.05 in the SHHO hospital.The patients were randomly divided into two groups. Patients in Group Ⅰ were given mosapride and lansoprazole. Patients with Helicobacter pylori infection were given eradiation treatment. Group Ⅱ, based on the therapy of Group I, add sulpiride of 50 mg per time and tree times per day before dinner for 4 weeks continually. Evaluate the therapeutic effect after drug withdrawal and half a year for two times. Score the symptoms, including epigastric pain, epigastric fullness, aerophagia, nausea, vomiting .etc, observe the process, and evaluate its efficacy.Results: 212 cases completed the treaunent, 82 cases of Group Ⅰ take a improvement percentage of 50.00%, 98 cases of group Ⅱ take a improvement percenlage of 78.57%.Conclusion: FD patients taking sulpiride on the bases of their original treatment could improve QOL.The efficacy could last longer even after drugs withdrawal.
出处
《中外医学研究》
2013年第17期3-4,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH