摘要
动脉粥样硬化的发生发展与低密度脂蛋白受到氧化修饰有关。本文从以下四个方面对本室的工作进行了综述：（１）动脉粥样硬化机体受到脂质过氧化损伤；（２）Ｏｘ－ＬＤＬ对内皮细胞、平滑肌细胞和巨噬细胞的毒性效应；（３）Ｏｘ－ＬＤＬ和ＭＤＡ－ＬＤＬ的比较及与Ｏｘ－ＬＤＬ和ＭＤＡ－ＬＤＬ结合的清道夫受体的特征；（４）不同方法对ＬＤＬ氧化修饰的比较和以ＬＤＬ氧化修饰为模型对某些物质的抗氧化修饰研究。研究结果为动脉粥样硬化发生机理的深入研究及临床防治提供了实验依据。
Our study, together with other's works, showed a close relationship between thedevelopment of atherosclerosis and oxidative modification of low density lipoprotein (LDL). In thisrespect, we have performed following work: (1) lipoperoxidative damage to the body during thedevelopment of atherosclerosis; (2) cytotoxic effects of oxidatively modified LDL (Ox-LDL) onendothelial cells, smooth muscle cells and macrophages; (3) comparative study on Ox-LDL andmalondiddehyde-modified LDL (MDA-LDL) and the characteristics of scavenger receptor boundOx-LDL and MDA-LDL in macrophages; (4) comparative studies of oxidative modification ofLDL with various modified methods, as a model, some antioxidant were studied. The results wouldprovide the baizes for further studying on the mechanism of atherogenesis and clinical prophylaxiaand therapy of the patients with atherosclerosis.
出处
《生命科学》
CSCD
2000年第1期44-46,共3页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金
关键词
氧化修饰
低密度脂蛋白
动脉粥样硬化
发生机理
oxidatively modified low density lipoprotein
atherosclerosis
foamy cell
monoclonalantibodies
Polystictus versicolor polysaccharides
