尖锐湿疣患者合并淋菌及解脲脲支原体感染的相关性研究

Study on correlation between condyloma acuminate and Neisseria gonorrhoeae and Ureaplasma urealyticuminfections

目的探讨尖锐湿疣(CA)患者合并性传播疾病淋菌(NG)、解脲脲支原体(Uu)感染与CA复发的相关性,为临床提供治疗依据。方法回顾性分析2008年2月-2012年5月门诊就诊的140例经临床诊断为CA患者的临床资料,将其作为观察组,选择同期接受体检的120例无CA的患者作为对照组,对其体内的NG、Uu进行检测,并对CA患者随访半年,统计NG、Uu或NG+Uu合并感染的复发率。结果观察组140例CA患者中,有56例患者检出NG或Uu,检出率为40.0%;120例无CA患者中,有14例患者检出NG或Uu,检出率为11.7%,两组差异有统计学意义(P<0.05);观察组NG与Uu的检出率分别为10.0%、33.6%,对照组NG与Uu的检出率分别为1.7%、9.2%,两组之间差异有统计学意义(P<0.01);15例CA合并NG感染患者中,有5例复发(33.3%),49例CA合并Uu感染患者中,有18例患者复发(36.7%),56例单纯性CA患者中9例患者复发(16.1%),上述3组复发率差异有统计学意义。结论 CA合并NG或Uu感染患者较单纯性CA患者的复发率均要高,应注意对NG与Uu进行同时检测,并采取相应的治疗。

OBJECTIVE To investigate the correlation between the recurrence of condyloma acuminate （CA） and the sexually transmitted diseases including the Neisseria gonorrhoeae （NG）, Ureaplasma urealyticum （Uu） infec-tions so as to guide the clinical treatment. METHODS The clinical data of 140 cases of patients who were clinically diagnosed as CA from Feb 2008 to May 2012 were retrospectively analyzed and were set as the observation group, then at the same period 120 cases of patients without CA who received the physical examination were selected as the control group, the bodies NG and Uu were detected, and a 6-month follow-up was performed for the patients, then the reoccurrence rates of the NG, Uu or NG＋ Uu infections were statistically analyzed. RESULTS Of 140 cases of CA patients in the observation group, 56 patients were detected with NG or Uu, the the detection rate was 40.0%; of 120 cases of CA patients, 14 patients were detected NG or Uu with the detection rate of 11.7%, the difference between the two groups was statistically significantly （P〈0.05）. The detection rates of the NG and Uu in the observation group were 10.0% and 33.6% ,respecively, and the detection rates of the NG and Uu in the control group were 1.7% and 9.2% , respectively ,the difference between the two groups was statistically signifi-cant（P〈0.01）. Of 15 cases of CA patients complicated with NG infections, there were five （33.3%） cases of recurrence; of 49 cases of CA complicated with Uu infections, there were 18 （36.7%） patients relapsed; there were 9 of 56 （16. 1%） eases of patients with single CA patients relapsed, the difference in the reoccurrence rate between the three groups was statistically significant. CONCLUSION The reoccurrence rate is higher in the CA patients complicated with NG or Uu infections than in the patients with single CA, it is necessary to pay attention to the detection of NG and Uu and take the corresponding treatment measures.