摘要
目的研究西瑞香素在大鼠体内的组织分布。方法健康SD大鼠,单剂量腹腔注射西瑞香素12 mg.kg-1,并于给药后5,45,120 min后采集大鼠全血和心、肝、脾、肺、肾、胃、小肠、脑组织,利用HPLC测定血浆和各组织中西瑞香素的浓度。结果大鼠腹腔注射西瑞香素12 mg.kg-1后,在胃、脾脏中浓度较高,其他组织和血浆中较低。结论研究西瑞香素的组织分布特征可为该药的进一步研究开发和临床应用提供重要的参考依据。
OBJECTIVE To study the tissue distribution of daphnoretin in rats. METHODS A single dose of 12 mg ·kg-1 daphnoretin was administered to healthy SD rats via intraperitoneal injection （ip）. The blood and tissues of heart, liver, spleen, lung, kidney, stomach, small intestine, and brain were acquired at 5, 45 or 120 min after administration. The concentrations of daphnoretin in plasma and tissue samples were determined by HPLC. RESULTS After a single ip dose of 12 mg·kg-1 daphnoretin in rats, daphnoretin was mainly distributed in stomach and spleen. The concentrations of daphnoretin in other tissues and plasma were low. CONCLUSION This present investigation on daphnoretin tissue distribution provides important information to further study and clinic use of daphnoretin.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2013年第11期884-887,共4页
Chinese Pharmaceutical Journal
基金
国家"十一五""重大新药创制"科技重大专项(2009ZX09301-012)
