小叶香茶菜中二萜类化学成分的研究

Study of diterpenoids constituents from Isodon parvifolius

目的研究云南中甸产的小叶香茶菜地上部分的二萜化学成分。方法采用硅胶色谱,半制备、制备HPLC分离纯化二萜化学成分,运用1HNMR、13CNMR、ESI-MS等技术鉴定结构。结果从云南中甸的小叶香茶菜地上部分共分离得到了14个二萜化合物,分别鉴定为hebeirubescensin L(Ⅰ),adenolin E(Ⅱ),trichokaurin(Ⅲ),effusanin B(Ⅳ),rabdoternin C(Ⅴ),baiyecrystal A(Ⅵ),rabdoternin A(Ⅶ),rabescensin C(Ⅷ),sodoponin(Ⅸ),longikaurin E(Ⅹ),rabdolasional(Ⅺ),isodonal(Ⅻ),trichorabdal A(ⅩⅢ),trichorabdal H(ⅩⅣ)。结论化合物Ⅶ、Ⅷ、Ⅻ和ⅩⅣ为首次从小叶香茶菜中分离得到。

OBJECTIVE To study the chemical diterpenaids constituents of Isodon parvifolius（Batalin） H.Hara.METHODS Chemical constituents were isolated by solvent-extraction together with column chromatography and the structures were determined by spectroscopic analysis.RESULTS Fourteen deterpenoides were isolated from the air part of Isodon parvifolius,and their structures were identified as hebeirubescensin L（Ⅰ）,adenolin E（Ⅱ）,trichokaurin（Ⅲ）,effusanin B（Ⅳ）,rabdoternin C（Ⅴ）,baiyecrystal A（Ⅵ）,rabdoternin A（Ⅶ）,rubescensin C（Ⅷ）,sodoponin（Ⅸ）,longikaurin E（Ⅹ）,rabdolasional（Ⅺ）,isodonal（Ⅻ）,trichorabdal A（ⅩⅢ）and trichorabdal H（ⅩⅣ）.CONCLUSION Compounds Ⅶ、Ⅷ、Ⅻ、ⅩⅣare obtained from Isodon parvifolius for the first time.