IGF系统与肿瘤

IGF System and Tumor

胰岛素样生长因子(IGFs)、胰岛素样生长因子结合蛋白(IGFBPs)和IGFBP蛋白酶,共同构成了IGF信号传导系统。IGFs主要参与调节细胞的增殖及凋亡过程,在肿瘤发生中的作用越来越受关注;IGFBPs作为一种诱导凋亡的重要蛋白,控制着IGFs受体的活性,在血循环中起着IGFs载体的作用,目前其与恶性肿瘤的关系也日益受到人们重视。

IGFs, IGFBPs and IGFBP protease compose the IGF signal transduction system. IGFs regulate the proliferation and apoptosis of cells, and the function in the process of tumor has gained more and more attentions. As apoptosis - induced proteins, IGFBPs control the activity of IGF receptors, and play a role as IGF carriers. Nowadays, many studies show clear evidence on the relation between IGFBPs and tumorigenesis.