方和谦经验方加味和肝汤治疗慢性浅表性胃炎临床研究

Clinical study of FANG He-qian's proved recipe Jiaweihegan decoction on chronic superficial gastritis

目的观察以方和谦教授经验方加味和肝汤治疗慢性浅表性胃炎临床疗效。方法按照随机对照试验将130例慢性浅表性胃炎患者随机分为加味和肝汤组50例、辨证治疗组40例和常规西药组40例。分别采用口服加味和肝汤、中医药辨证汤剂及西药吉法酯治疗。3组均以30天为1个疗程,共治疗2个疗程。比较3组治疗前后症状体征以及胃镜疗效。结果加味和肝汤组症状积分下降较辨证治疗组、常规西药组均明显,差异均有统计学意义(P<0.05);3组间症状总有效率比较差异有统计学意义(χ2=13.582,P<0.01);加味和肝汤组胃镜有效率达84.0%,3组间胃镜疗效总有效率比较差异有统计学意义(χ2=6.546,P<0.05)。结论加味和肝汤可以明显改善患者临床症状及胃镜下表现。

Objective To observe the clinical efficacy of Professor FANG He-qian＇s proved recipe,Jiaweihegan decoction on chronic superficial gastritis.Methods According to randomized controlled trial,one hundred and thirty cases of chronic superficial gastritis were randomly divided into a Jiaweihegan decoction group（JD group,n=50） that was orally administrated Jiaweihegan decoction,a syndrome differentiation group（SD group,n=40） treated with syndrome differentiation decoctions and a conventional Western medicine group（WM group,n=40） that was orally administrated gefarnate.30 days composed one course of treatment and 2 courses were required.The symptoms,signs and efficacy observed by gastroscope before and after the treatment were compared in the three groups.Results The symptom score in the JD group was more obviously decreased than that in the SD group and the WM group（P0.05）;there was significant between-group difference in total effective rate of symptom efficacy（χ2=13.582,P0.01）;in the JD group,the effective rate by gastroscope reached 84%,and there was significant between-group difference in total effective rate by gastroscope（χ2=6.546,P0.05）.Conclusion Jiaweihegan decoction could apparently improve the clinical symptoms and manifestations under gastroscope.