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恶性肿瘤的帮凶——纤维母细胞活化蛋白 被引量：2

Fibroblast Activation Protein——the Accomplice of Malignant Tumor
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摘要 成纤维细胞活化蛋白(fibroblast activation protein,FAP)是一种丝氨酸蛋白酶,主要由活化的成纤维细胞分泌,广泛存在于上皮来源的恶性肿瘤中,与恶性肿瘤的侵袭和转移、血管形成、免疫逃逸等密切相关。综述FAP的结构和功能、在恶性肿瘤中的表达情况、与恶性肿瘤的关系及在恶性肿瘤诊断与治疗中的应用,并对FAP在肿瘤诊治中的应用前景进行展望。 Fibroblast activation protein（FAP）is a kind of serine protease,mainly secreted by activated fibroblast,widely exist in epithelial tumors.The close relationship of FAP with the invasion,metastasis,angiogenesis and immune escape of tumors have been confirmed.This is a review about FAP of the structure and functions,the expression and mechanism of action in tumors,the application in diagnosis and treatment for tumors.At last,prospects for the usage of FAP in tumors.
作者 黄天明 莫发荣 罗国容
机构地区 广西医科大学组织学与胚胎学教研室
出处 《生物技术通报》 CAS CSCD 北大核心 2013年第5期34-39,共6页 Biotechnology Bulletin
基金 国家自然科学基金项目(81160264) 广西自然科学基金重点项目(2010GXNSFD013048)
关键词 成纤维细胞活化蛋白 恶性肿瘤 微环境 Fibroblast activation protein Malignant tumor Microenvironment
分类号 R730.2 [医药卫生—肿瘤]
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参考文献51

  • 1Klein G, Sjogren HO, Klein E, et al. Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host[J]. Cancer Res, 1960, 20:1561-1572.
  • 2Mathew S, Scanlan MJ, Mohan Raj BK, et al. The gene for fibroblast activation protein alpha(FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23[J]. Genomics, 1995, 25:335-337.
  • 3Pi?eiro-Sánchez ML, Goldstein LA, Dodt J, et al. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease [J]. J Biol Chem, 1997, 272(12):7595-7601.
  • 4Cheng JD, Valianou M, Canutescu AA, et al. Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth[J].Mol Cancer Ther, 2005, 4(3):351-360.
  • 5Gorrell MD, Gysbers V, McCaughan GW. CD26:a multifunctional integral membrane and secreted protein of activated lymphocy-tes[J]. Scand J Immunol, 2001, 54(3):249-264.
  • 6Kelly T. Evaluation of seprase activity[J]. Clin Exp Metastasis, 1999, 17(1):57-62.
  • 7Chen WT, Kelly T. Seprase complexes in cellular invasiveness[J].Cancer Metastasis Rev, 2003, 22(2-3):259-269.
  • 8Artym VV, Kindzelskii AL, Chen WT, et al. Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes:dependence on beta1 integrins and the cytoskeleton[J]. Carcinogenesis, 2002, 23(10):1593-1601.
  • 9Mueller SC, Ghersi G, Akiyama SK, et al. A novel protease-docking function of integrin at invadopodia[J]. J Biol Chem, 1999, 274(35):24947-24952.
  • 10Garin-Chesa P, Old LJ, Rettig WJ. Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers[J]. Proc Natl Acad Sci USA, 1990, 87(18):7235-7239.

二级参考文献16

  • 1CHENG J D,WEINER L M.Tumors and theirmicroenvironments:tilling the soil. Clinical Cancer Research . 2003
  • 2Liotta LA,Kohn EC.The microenvironment of the tumour-host interface. Nature . 2001
  • 3Kunz-Schughart LA,Knuechel R.Tumor-associated fibroblasts (part I): active stromal participants in tumor development and progression. Histology and Histopathology . 2002
  • 4Micke P,Ostman A.Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy. Lung Cancer . 2004
  • 5Olivier De Wever,Marc Mareel.Role of tissue stroma in cancer cell invasion. Journal of Insect Pathology . 2003
  • 6Sappino AP,Schurch W,Gabbiani G.Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Laboratory Investigation . 1990
  • 7Acharya P S,,Zukas A,Chandan V,et al.Fibroblast activation protein:a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis. Human Pathology . 2006
  • 8Rosenblum JS,Kozarich JW.Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. Current Opinion in Chemical Biology . 2003
  • 9Milner J M,Kevorkian L,Young D A,et al.Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. J Arthritis Res Ther . 2006
  • 10Rubin,H.Selected cell and selective microenvironment in neoplastic development. Cancer Research . 2001

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生物技术通报
2013年 第5期

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