经纤支镜和经皮联合植入125I粒子治疗晚期肺癌气管狭窄的临床分析

The clinical analysis of 125I particles implantation by fibrobronchoscope and percutaneous in the treatment of tracheal stenosis of advanced lung cancer

目的评价125I粒子植入治疗晚期肺癌中气管狭窄的临床疗效。方法收集晚期肺癌患者18例，将125I粒子经纤支镜插入病变气道进行植入治疗，每例患者植入粒子数为4～15粒。采用CT检查比较粒子植入前、术后30、60、180d的肿瘤大小，并分析其临床症状变化。结果18例患者术后l周气急症状均减轻，30d后有16例胸部CT检查显示支气管管腔扩大，13例阻塞性肺炎症状消失。随访期间所有患者均未出现严重并发症。结论125I粒子植入治疗晚期肺癌中气管狭窄的效果良好、操作安全，可作为治疗晚期肺癌气管狭窄的有效方法，并值得进一步推广。

Objective To evaluate the clinical efficacy of 125I particles implantation in the treatment of tracheal stenosis due to advanced lung cancer. Methods Eighteen cases with end stage lung cancer were collected. 125I particles were implanted by inserting the bronchoscope into the pathological bronchial tubes of distal puncture. The number of 125I particles implanted ranged from 4-15. The tumor sizes were compared before and 30 d, 60 d, 180 d after the nsI particles implantation according to the examination of CT, and the clinical symptoms were studied. Results The symptoms of shortness of breath were relieved after 125I pani- cles implantation. Thirty days follow-up after the therapy showed 15 cases of enlarged bronchial lumen, 13 cases of disappeared obstructive pneumonia symptoms, and no obvious complication occurred during the fol- low-up. Conclusion The implantation of 126I radioactive particles has a good effect for the tracheal stenosis in the treatment of advanced lung cancer; the therapy is safe and worth to be spread.