癌干细胞与肿瘤的放射抗性

Cancer stem cell and its relevance to tumors resistance to radiotherapy

有关癌干细胞及其生物学特性研究信息的不断积累，推动了放射肿瘤生物学的发展。近年来的研究发现，癌干细胞和静止期癌细胞可能是导致肿瘤放射抗性增加和肿瘤放射治疗后复发的主要细胞学基础，有关这两种癌细胞亚群的放射敏感性及其机制的研究进展迅速，为提高肿瘤对放射治疗敏感性的措施研究提供了新的学术思路。该文将就癌细胞亚群的放射分子生物学特性，分析讨论肿瘤放射抗性的细胞学基础和相关分子机制。

The gradually accumulated information and knowledge regarding cancer stem cell or stem-like cancer cell greatly potentiated the research progression of radiation oncology and biology. In recent yeats, a series studies have uncovered that the cancer stem cell and cancer quiescent cell could be the major ceils origin attributed to the radioresistance and recurrence of tumors in the course of radiotherapy. A rapid research progression has already been achieved respecting the radiosensitivity and related mechanisms of these two subsets of cancer ceils, and which provides an idea strategy for development of the measures target- ing tumor radioresistance. This paper reviewed and discussed the cellular basis and molecular mechanism of the tumor radioresistance from the aspects of cancer ceils subsets and the radiobiological characteristics.