慢性阻塞性肺疾病不同时期病原体分布及其与疾病的关系

Pathogen distribution of chronic obstructive pulmonary disease in different periods and relationship

慢性阻塞性肺疾病（COPD）是呼吸系统的常见病、多发病，是一种以气流受限不完全可逆为特征的疾病。病原体感染及下呼吸道细菌定植是COPD加重、恶化的重要因素，并与疾病的发生、发展相关联。通过对COPD不同时期病原体分布及负荷情况动态监测，了解其与疾病之间的关联，以期对COPD的各个时期给予相应干预，达到预防发作、缩短病程、改善预后的目的。

Chronic obstructive pulmonary disease （COPD） is a common disease of the respiratory system disease, the disease characterized is the airflow limitation is not fully reversible. Pathogen infection and lower respiratory tract bacterial colonization is the important factors of COPD exacerbations and the deterioration, and development associated with the occurrence of the disease. Dynamic monitoring of pathogen distribution and load through different periods of COPD, fang out its association with disease, in order to give appropriate intervention in various periods of COPD to the purpose of prevent seizures, shorten the course and improving the prognosis.