不同证型急性脑梗死患者血浆Hcy与vWF检测意义分析

Clinical significance of Hcy and vWF patients with two types of syndromes of acute cerebral infarction

目的探讨阴虚风动证和风痰瘀阻证急性脑梗死(ACI)患者血浆同型半胱氨酸(Hcy)与血管性血友病因子(vWF)检测的临床意义。方法测定阴虚风动证和风痰瘀阻证ACI患者各80例及健康者20例(对照组)血浆vWF及Hcy水平,比较组间差异及不同证型组内二者的相关性。结果两种证型ACI患者血浆vWF及Hcy水平均高于对照组,风痰瘀阻证ACI患者血浆vWF及Hcy水平高于阴虚风动证ACI患者(P<0.05);不同症型ACI患者血浆Hcy与vWF水平呈正相关(P<0.05)。结论 Hcy与vWF水平升高是诱发两种症型ACI的重要危险因素,检测二者水平能够为ACI证型分析提供客观依据。

Objective To study the clinical significance of homocysteine（Hcy） and von Willebrand factor（vWF） in patients with acute cerebral infarction of wind due to Yin deficiency syndrome（WYDS） and wind-phlegm syndrome and stasis（WPSS）.Methods Plasma levels of Hcy and vWF in patients with ACI of WYDS and with ACI of WPSS,80 cases for each,and 20 cases of healthy controls were detected.Differences of Hcy and vWF levels between different groups were statistically compared and correlation between the two indicators in the two different patient groups was analyzed.Results Plasma levels of vWF and Hcy in the two different patient groups were higher than control group,and those in ACI of WPSS group were higher than in ACI of WYDS group（P0.05）.There was positive correlation between vWF and Hcy in these two different patient groups（P0.05）.Conclusion Increasing of Hcy and vWF level might be important risk factors of ACI for the two types of syndromes.Detection of these two indicators might be helpful for the analysis of syndromes of ACI.