228株铜绿假单胞菌临床分布及耐药性分析

Clinical distribution and drug resistance of 228 strains of Pseudomonas aeruginosa

目的分析铜绿假单胞菌(PAE)临床分布特点及耐药性,为临床合理用药提供依据。方法回顾性分析本院2010年5月至2011年12月分离的228株PAE临床分布特点及耐药性。结果 228株PAE主要来源于呼吸内科、重症监护病房和脑外科,分别占36.9%、27.2%和23.2%;阳性标本主要为痰液,占72.4%;对头孢哌酮/舒巴坦、亚胺培南、美罗培南和阿卡米星耐药率较低,分别为0.0%、8.9%、9.6%和8.3%;对氨苄西林、头孢唑啉和头孢噻肟耐药率大于67.0%;对头孢他啶、头孢吡肟和哌拉西林/他唑巴坦耐药率小于30.0%。结论 PEA耐药性较强,应加强耐药性监测,规范抗菌药物的应用。

Objective To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa（PAE） to provide references for rational usage of antibiotics in clinic.Methods The characteristics of clinical distribution and drug resistance of 228 strains of PAE,isolated from May.2010 to Dec.2011 in this hospital,were retrospectively analyzed.Results Among 228 PAE isolates,most were collected from Respiratory Department,ICU and Department of Cerebral Surgery,accounting for 36.9%,27.2% and 23.2%.165 strains were isolated from sputum,accounting for 72.4%.The drug resistance rates of PAE to cefoperazone/sulbactam,imipenem,meropenem and amikacin were 0.0%,8.9%,9.6% and 8.3% respectively,to ampicillin,cefazolin and cefotaxime were higher than 67.0% and to ceftazidime,cefepime and piperacillin/tazobactam were lower than 30.0%.Conclusion The drug resistance of PAE might be serious.It should be strengthened to reinforce the monitoring on drug resistance and to standardize the application of antibacterials.