卵母细胞凋亡的研究进展

Research Progress on Oocyte Apoptosis

对于复杂多细胞生物体来说,严格控制细胞增殖与死亡对细胞功能的协调是非常必要的,而限制体内异常细胞增殖最重要的一种方式就是细胞凋亡。女性生殖细胞的凋亡是卵泡实现募集、选择和优势化的重要途径。近年对于卵母细胞凋亡研究的热点主要集中在Bcl-2家族的调控机制,以及凋亡对胚胎生长发育的影响。

To multicellular organisms, it is very necessary for cellular function coordination to control cell proliferation and death. Cell apoptosis is just the most important pattern to limit the proliferation of abnormal cells. The female germ cell apoptosis is an important way for follicle recuitment, selection and dominance. Recently, the research spots on oocyte apoptosis are the regulation mechanisms of Bcl-2 family, and its impact on embryo development.