异位妊娠发生机制研究进展及辅助生殖技术相关高危因素分析

Current Knowledge of the Aetiology and Risk Factors of Human Ectopic Pregnancy after Assisted Reproductive Technology

辅助生殖技术(ART)后异位妊娠发生风险增高。临床研究发现,输卵管因素不孕、超生理的激素环境、ART操作以及胚胎发育潜能等是ART后异位妊娠的高危因素。分子机制研究大多为描述性研究,在炎症、激素水平及ART操作等方面发现了一些和异位妊娠发生相关的因子。这些因子可能通过参与影响输卵管运输功能、输卵管内环境和(或)胚胎本身因素导致胚胎异位种植,也可能只是异位种植的结局表现。深入了解ART后异位妊娠发生的机制及相关高危因素,有助于改进ART技术,预防ART后异位妊娠发生。

The risk of ectopic pregnancy m pregnancies resumng irom asslsteu reproductive technology （ART） than in spontaneous pregnancies. Clinical studies showed that tubal factor infertility,different hormonal milieu,ART procedures,and embryo implantation potential were potential risk factors. At present, most reports were descriptive on the molecular mechanism of tubal cctopic pregnancy. Limited data revealed that some molecules may play roles in EP pathogenesis, which related to infection,hormonal abnormality and ART procedures. Those molecules may involve in the mechanism of embryo ectopic implantation through their impact on tubal transfer function,tubal environment and/or embryo factors. But, the changed expressions of those molecules could he simply the result of tubal implantation. Further understanding the aetiology and risk factors of tubal ectopic pregnancy is critical for us to improve ART procedures and prevent EP.