复发卵巢癌患者生命质量的研究进展

Quality of Life for Patients with Recurrent Ovarian Cancer

绝大多数卵巢癌患者初诊时已属中晚期,并将面临复发,复发后患者的生命质量将明显下降。目前认为,复发卵巢癌患者的生命质量主要受到疾病本身及相关治疗的影响。例如肿瘤复发引起的肠梗阻、胸腹水等症状,脏器切除导致的并发症以及化疗带来的不良反应等,从多方面影响了患者正常的生理功能。此外,因治疗产生的脱发、性功能减退等不良结局以及对预后的担忧都将引起患者的负面情绪,从而降低生活质量。如何同时提高患者的生存与生命质量已成为复发卵巢癌的治疗目标。

Most patients with ovarian cancer were diagnosed at the advanced stages, and would eventually recur. The quality of life （QOL）of these patients will be diminished while experiencing recurrence. Generally, the QOL of patients with recurrent ovarian cancer is affected by disease itself and treatment. Many physiological functions are changed owing to the recurrent symptoms, such as bowel obstruction, ascites and pleural effusion, the postoperative complications of cytoreductive surgery, and the side-effects of chemotherapy. Besides, the psychological distress caused by bad endings of treatment, such as alopecia, and sexual dysfunction, and fear of poor prognosis, will result in lower QOL. The therapeutic goals for patients with recurrent ovarian cancer should be aimed to imlarove their both survivals and OOL.