黄荆的化学成分研究

Chemical constituents from Vitex negundo

目的研究黄荆Vitex negundo的化学成分。方法采用十八烷基硅烷键合硅胶(ODS)、葡聚糖凝胶Sephadex LH-20和硅胶柱色谱等色谱技术,对黄荆的化学成分进行分离纯化,通过波谱数据分析,鉴定了化合物的结构。结果从黄荆95%乙醇提取物正丁醇萃取部位分离得到11个化合物,分别鉴定为异荭草素(1)、黄荆诺苷(2)、木犀草素7-O-β-D-吡喃葡萄糖苷(3)、异牡荆苷(4)、木犀草素3′-O-β-D-吡喃葡萄糖醛酸苷(5)、芹菜素7-O-β-D-葡萄糖苷(6)、山柰酚3-O-β-D-吡喃葡萄糖苷(7)、迷迭香酸甲酯(8)、5-O-咖啡酰基-奎宁酸甲酯(9)、咖啡酸(10)及银桦苷G(11)。结论化合物5～11为首次从牡荆属植物中分离得到,化合物3、4为首次从该植物中分离得到。

Objective To investigate the chemical constituents from Vitex negundo.Methods The chemical constituents were separated and purified by column chromatography including ODS,Sephadex LH-20,and silica gel columns.Their structures were elucidated on the basis of physicochemical properties and spectral data.Results Eleven compounds were identified as isoorientin（1）,vitegnoside（2）,luteolin-7-O-β-D-glucopyranoside（3）,isovitexin（4）,luetolin-3′-O-β-D-glucuronide（5）,apigenin-7-O-β-D-glucoside（6）,kaempferol-3-O-β-D-glucopyranoside（7）,methyl rosmarinate（8）,5-O-caffeoyl quinic acid methylester（9）,caffeic acid（10）,and grevilloside G（11）,respectively.Conclusion Compounds 3 and 4 are isolated from V.negundo for the first time,and compounds 5—11 are firstly obtained from the plants of Vitex Linn.