依达拉奉联合盐酸法舒地尔治疗西宁地区急性脑梗死的疗效观察

Effect of Edaravone Combined with Hydrochloric Fasudil on Acute Cerebral Infarction in Xining Area

目的:探讨依达拉奉与盐酸法舒地尔联合治疗高原地区急性脑梗死的疗效和安全性。方法:选取66例高原地区急性脑梗死患者,并随机分成治疗组(依达拉奉+盐酸法舒地尔)34例和对照组(依达拉奉)32例,观察两组治疗前后血清神经元特异性烯醇化酶(NSE)、美国国立卫生研究院卒中量表(NIHSS)和日常生活活动能力量表(BI)评分的变化,并比较出血率及肝、肾功能损害的发生率。结果:两组治疗后血清NSE较治疗前均有明显下降(P<0.05);两组间比较治疗组较对照组NSE水平下降更明显(P<0.05)。两组治疗后NIHSS评分、BI评分比较显示治疗组较对照组的神经功能恢复得更好(P<0.05)。两组出血发生率比较差异无显著性(P>0.05)。所有病例无严重不良反应发生。结论:依达拉奉联合盐酸法舒地尔治疗高原地区急性脑梗死安全、有效。

Objective：To observe effect and safety of edaravone combined with hydrochloric tasudil on acute cerebral infarction at high altitude. Methods：66 cases of acute cerebral infarction identified by CT and MRI were randomly divided into the treatment group （n = 34） to give edaravone ＋ fasudil hydrochloride） and the control group （ n = 32） to received edaravone only. Serum level of neuron specific enolase （NSE） was detected before and after treatment in the both groups. And NIH Stroke Scale （NIHSS） , score of activities of daily living scale （ Barthel Index, BI） were recorded; the bleeding rate, damaging function of liver and kidney were compared between the two groups. Results：The level of NSE after treatment was decreased obviously in the both groups compared with before treatment （ P 〈 0.05 ）, but decreased NSE was more significant in the treatment group as compared with the control group （P 〈 0.05 ）. NIHSS and BI score after treatment suggested that neural function in treatment group was better recovery than in the control group （ P 〈 0.05 ）. There was no a significant difference in bleeding rate be- tween the two groups （ P 〉 0.05 ）. Conclusions： Therapy of edaravone combined with fasudil hydrochloride is efficacy and safety for acute cerebral infarction at high altitude.