期刊文献+

阿托伐他汀短期应用对慢性心衰患者功能的影响

原文传递
导出
摘要 目的:观察阿托伐他汀短期治疗对慢性心力衰竭患者心功能的作用。方法:86例慢性心力衰竭患者(NYHA分级Ⅱ级~Ⅲ级)随机分为两组,治疗组(46例)和对照组(40例)。对照组给予常规抗心衰治疗,治疗组在此基础上加用阿托伐他汀20mg/d,共6周。治疗前检查心脏超声,评估心功能和血脂水平。结果:6周后治疗组总胆固醇、甘油三酯,低密度脂蛋白水平明显降低(P<0.05),左室射血分数有明显提高(P<0.05),两组心功能改善有显著差异(P<0.05)。结论:阿托伐他汀能改善心脏功能,短期治疗对慢性心力衰竭有效。
作者 王晓云
出处 《青海医药杂志》 2013年第2期29-30,共2页 Qinghai Medical Journal
  • 相关文献

参考文献5

  • 1Hennandez Presa MA, Martin - Ventura JL, Ortego M, et al. Atorvastatin reduces the expression of cycloxgenase - 2in a rabbit model of atherosclemsis and in cultured vascular smooth muscle cell. Athemselerosis,2002,160( 1 ) :49 -58.
  • 2Hidekatsu F, David CS, Stefen B ,et al. Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report. Circulation, 2005,112 : 357 363.
  • 3Khush KK, Waters DD, Bitter V, et al. Effect of high doss atorvasatin on hospitalizations for heart failure :subgroup a- nalysis of the Treating to New Targets(TNT) study. Circula- tin ,2007,115 ( 5 ) :576 - 583.
  • 4马义平,廖东承,田武生.阿托伐他汀治疗对慢性心衰患者心功能和细胞因子的影响[J].临床医学,2006,26(5):11-12. 被引量:4
  • 5Node K, Fujita M, Kitakaze M, et al. Short - term statin thera- py improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation,2003,108 : 839 - 843.

二级参考文献5

  • 1Ferro D,Parrotto S, Basili S,et al. Simvastatin inhibits the monocyte expression of proinflammatory cytokines in patients with hypercholesterolemia. J Ama Coll Cardiol,2000,36(2) :427.
  • 2Hernandez - Presa MA, Martin - Ventura JL, Ortego M, et al. Atorvastatin reduces the expression of cyclooxgenase - 2 in a rabbit model of atherosclerosis and in cultured vascular smooth muscle cells. Atherosclerosis,2002,160( 1 ) :49 -58,
  • 3Torre -Amione G, Kapadia S, Benedict S,et al. Proinflammatory cytokine levels in patients with depressed left ventricular ejection tion: a report from the study of left ventricular dysfunction(SOLVD). J Am Coll Cardiol,1996,27 (5) :1201.
  • 4Hidekatsu F, David CS,Steffen B ,et al. Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report. Circulation ,2005,112:357 - 363.
  • 5Node K, Fujita M ,Kitakaze M ,et al. Short - term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation ,2003,108:839 - 843.

共引文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部