他汀类药物致横纹肌溶解综合征及文献复习

Rhabdomyolysis due to irrational use of statins and literature review

他汀类药物在动脉粥样硬化疾病的治疗和预防中得到广泛的应用,但需要注意发生肌病的风险。1例合并慢性肾脏病的高龄女性急性冠脉综合征患者,由于将辛伐他汀剂量加倍,导致发生了横纹肌溶解综合征,停药并应用血液滤过治疗后病情得到缓解。其发病机制可能与他汀类药物引起的异戊二烯或辅酶Q10缺乏有关。合并慢性肾脏病时,他汀类药物容易在体内蓄积,并导致严重的药物不良反应。

Statins are widely used for prevention and treatment of atherosclerosis, constant vigilance is necessary in order to avoid myopathy. In an old female patient with chronic kidney disease complicated by acute coronary syndrome,rhabdomyolysis occured due to double dose of simvastatin, she recovered after drug withdrawal and use of hemofiltration. The pathogenesis may be statin-induced isoprenoid or ubiquinon deficiency. In chronic kidney disease, statins tend to accumulate in human body, and cause severe adverse drug reaction.