石家庄市健康体检人群尿微量白蛋白和β_2微球蛋白分析

ANALYSIS OF MICROALBUMINURIA AND β_2 MICROGLOBULIN ON HEALTHY EXAMINATION POPULATION OF SHIJIAZHUANG

目的探讨尿微量白蛋白和β_2微球蛋白在健康体检中的应用价值。方法应用比浊法检测417例健康体检者尿微量白蛋白和β_2微球蛋白含量,并将其结果与其他检测指标进行相关性分析。结果尿微量白蛋白和β_2微球蛋白在性别中差异有统计学意义(P<0.05);尿微量白蛋白和β_2微球蛋白与收缩压、尿比重、血尿素氮、肌酐等检测指标均呈正相关(P<0.05)。此外,尿微量白蛋白与β_2微球蛋白也呈正相关(P<0.01)。结论在制定普通人群中尿微量白蛋白和β_2微球蛋白的正常范围时,应该注意性别的差异;尿微量自蛋白和β_2微球蛋白作为反映肾功能的敏感指标,可用于健康体检。

Objective To investigate the application value and related risk factors of microalbuminuria and β2 microglobulin in health examination. Methods Microalbuminuria and β2 microglobulin of 417 healthy cases were detected by turbidimetric assay. The analysis correlation between microalbuminuria, β2 microglobulin and other indexes were analyzed. Results There were significant differences in microalbuminuria and β2 microglobulin between males and females （ P 〈 0. 01 ）. Microalbuminuria and β2 microglobulin showed statistically significant positive correlation with systolic blood pressure, urine specific gravity, blood urea nitrogen, creatinine and so on （ P 〈 0.05 ）. In addition, microalbuminuria and β2 microglobulin were also positively correlated （P 〈 0.05）. Conclusion Gender differences should be paid more attention in formulating the normal range of the microalbuminuria and β2 microglobu!in. As sensitive indexes of renal function in physical examination population, microalbuminuria and β2 microglobulin can be used in health examination.