活性氧在青蒿素及其衍生物抗肿瘤作用机制中的研究进展

青蒿素及其衍生物目前已成为抗疟的一线药物,近年来,很多研究已经证实青蒿素及其衍生物具有明显的抗肿瘤作用。其细胞毒性效应主要与活性氧(ROS)的产生有关。其可能作用靶点包括血红素、线粒体及某些特定的蛋白等。其抗肿瘤作用包括抑制肿瘤细胞增殖、抑制肿瘤新生血管生成、抗肿瘤细胞侵袭和转移,以及促进肿瘤细胞凋亡等。青蒿素类药物广谱、高效、低毒,能选择性杀伤肿瘤细胞,逆转肿瘤的多重耐药现象,与多种化疗药物具有协同、增效作用,有望被开发成为新型抗肿瘤药。

The artemisinin and its derivatives are the frontline drugs for the treatment of malaria at present, which has been proved to have significant anti-tumor effects in recent years. Its cytotoxic effect is primarily concerned with the generation of active oxygen species （ROS）. The possible targets including heine, mitochondrial and certain proteins. Its anti-tumor effects including inhibition of proliferation, angiogenesis, invasion and metastasis of tumor cells, induction of apoptosis. In summary, the artemisinin compounds,which with broad-spectrum, high efficiency, and low toxicity, can selectively kill cancer cells, retroconverse themultidrug resistance for cancer cells,and also have chemosensitizing/synergistic effects with many chemotherapy drags.Therefor, they are expected to be developed as new anticancer drugs.