2-正丁基-5-甲酰基咪唑的合成
摘要
以2-正丁基-1H-咪唑-4-酮(2)为原料,经过双(三氯甲基)碳酸酯(3)氯化甲酰化,再经Raney-Ni催化氢化得2-正丁基-5-甲酰基咪唑(1)。用正交试验确定了最佳合成工艺:n(2):n(3)=1.0:1.2,DMF=30%,反应温度=100℃,反应时间=6h,收率在76%以上。目标化合物用MS和1H NMR表征。
出处
《中国医药指南》
2013年第11期70-71,共2页
Guide of China Medicine
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