米氮平与小剂量阿米替林治疗老年抑郁症伴严重失眠的疗效比较分析

The Analysis of Treating Senile Depression Combined Severe Insomnia with Mirtazapine or Small Dose of Amitriptyline

目的具体探讨对于老年抑郁症伴严重失眠患者进行治疗中采用米氮平与小剂量阿米替林的临床疗效,为老年抑郁症患者的临床治疗工作提供可行性的参考。方法对我院收治的116例患者随机分为治疗组(米氮平治疗)和对照组(小剂量阿米替林治疗)两组,对两组患者临床治疗效果进行全面对比分析。结果从临床疗效对比情况上来看,研究组患者的总有效率明显高于对照组,两组差异性具有统计学意义(P<0.05)。结论相对于小剂量阿米替林的临床应用效果来看,米氮平的治疗效果更为明显且不良反应发生概率小,值得推广应用。

Objective To discuss the clinical effect of treating senile depression combined severe insomnia with mirtazapine or small dose of amitriptyline. Methods To divide patients into study group treated with mirtazapine and controlled group treated with small dose of amitriptyline. Compared the clinical effect of these two groups. Results The total effect in study group was higher than controlled group （P〈0.05）. Conclusion Compared with small dose of amitriptyline, treating senile depression combined severe insomnia is better with less adverse effect to extend in clinic.