用丙硫咪唑治疗多房棘球蚴病的研究

The Treatment of AHD with Albendazole: A Clinical Study

多房棘球蚴病(Multilocular hydatid disease)也称泡状球蚴病(Alueolar hydatid disease),系多房棘球绦虫(Echinococcusmultilocular)的幼虫寄生于人体或动物体引起的最险恶的寄生虫病。为研究药物治疗的方法,1983年我们给人工感染多房棘球蚴病的白鼠和自然感染单房棘球蚴病(UHD)的绵羊口服丙硫咪唑(Albendazole)证实确有杀灭原头节(Protoscolex)作用。1984年与固原地区医院协作(提供资料和药品),

Clinical observations were carried out to study the application of albendazole to the treat ment of AHD and HD, which led more than one organ infected seriously because of the cyst's rupture or which could not be treated by operation again because of many times relapse after operation. The method of the treatment was that: taking albendazole at the dosages of 8-18mg / kg / d for 8-14 courses of the treatment, then stopping taking it for 3-4 months, if the patients still had the disease, they could take the drug again depending on the conditions. Through 5 years clinical observation and check and visit the main cases, the authors found that the method was safe, effective, the dosage and the course were reasonable, which could control the disease or reduce suffering and prolong life-time.