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ALDH1和上皮间质转化相关蛋白在三阴性乳腺癌中的表达及其相关性 被引量：4

Expression of ALDH1 and Epithelial-mesenchymal Transition-related Proteins in Triple Negative Breast Cancer and Their Correlations
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摘要 [目的]探讨三阴性乳腺癌(TNBC)组织中乙醛脱氢酶1(ALDH1)和上皮间质转化(EMT)相关蛋白的表达情况及其相关性。[方法]采用免疫组化方法检测90例TNBC组织中ALDH1以及EMT相关蛋白E-钙黏蛋白(E-cad)、N-钙黏蛋白(N-cad)的表达,分析其与临床病理特征的关系,并进一步分析ALDH1和EMT相关蛋白之间的相关性。[结果]TNBC组织中ALDH1、E-cad、N-cad的阳性表达率分别为45.6%(41/90)、56.7%(51/90)、52.2%(47/90)。淋巴结转移在不同ALDH1表达组间差异具有统计学意义(P<0.05),肿瘤大小、组织学分级、淋巴结转移在不同E-cad表达组间差异具有统计学意义(P<0.05),组织学分级、淋巴结转移在不同N-cad表达组间差异具有统计学意义(P<0.05)。ALDH1的表达与E-cad、N-cad的表达均相关(P<0.001),E-cad的表达与N-cad的表达也呈弱的负相关(r=-0.208,P=0.049)。[结论]TNBC组织中EMT参与了乳腺癌的发生、浸润、转移,并且能够增加乳腺癌组织中的干细胞表型。 [Purpose] To investigate the expressions of aldehyde dehydrogenase 1（ALDH1） and epithelial-mesenchymal transition（EMT）-related proteins in triple negative breast cancer（TNBC）and their correlations.[Methods] The expressions of ALDH1,E-cadherin（E-cad）,N-cadherin（N-cad） in 90 cases with TNBC were detected immunohistochemically.The relationship between the expressions of ALDH1,E-cadherin,N-cadherin and the clinicopathological characteristics was analyzed.The correlation between ALDH1 and EMT-related proteins was also analyzed.[Results] The positive rate of ALDH1,E-cad,N-cad was 45.6%（41/90）,56.7%（51/90）,52.2%（47/90） respectively in TNBC.The lymph node metastasis was significantly different between the positive and negative expression groups of ALDH1.The tumor size,histological grade,lymph node metastasis were significantly different between the positive and negative expression groups of E-cad.The histological grade,lymph node metastasis were significantly different between the positive and negative expression groups of N-cad.The expression of ALDH1 strongly correlated with the expressions of E-cad and N-cad（P0.001）.The expressions between E-cad and N-cad showed weak correlation（r=-0.208,P=0.049）.[Conclusion] EMT is involved in the occurrence,invasion and metastasis of TNBC and also increases the stem cell phenotype in the breast cancer tissue.
作者 姚宇锋 龚建平 秦建伟 唐金海
机构地区 江苏省肿瘤医院
出处 《肿瘤学杂志》 CAS 2013年第5期369-372,共4页 Journal of Chinese Oncology
基金 江苏省"333高层次人才培养工程"科研项目资助
关键词 乳腺肿瘤 乙醛脱氢酶1(ALDH1) 上皮间质转化 免疫组织化学 breast neoplasms aldehyde dehydrogenase 1（ALDH1） epithelial-mesenchymal transition immunohistochemistry
分类号 R737.9 [医药卫生—肿瘤]
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参考文献13

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二级参考文献11

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肿瘤学杂志
2013年 第5期

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