结肠腺癌中膜联蛋白A5的表达及其临床意义

Expression of Annexin A5 in Adenocarcinoma of Colon and Its Clinical Significance

[目的]研究膜联蛋白A5(Annexin A5)在结肠腺癌组织中的表达水平及其与临床病理因素之间的关系。[方法]应用蛋白质印迹法(Western blot)和S-P免疫组化法检测结肠腺癌组织和相应癌旁正常组织中Annexin A5表达状况。[结果]Annexin A5在结肠腺癌组织中的表达水平及阳性表达率均显著高于相应癌旁正常组织中的表达,差异具有显著性(P<0.05)。进一步研究表明,Annexin A5表达与肿瘤大小和患者是否发生淋巴结转移有关(P<0.05)。[结论]Annexin A5在结肠腺癌的形成和转移中有着重要作用,有望成为结肠腺癌临床治疗的新靶标。

[Purpose] To explore the expression of annexin A5 in adenocarcinoma of colon and the relationship between annexin A5 and clinicopathologic factors.[Methods] Expression of annexin A5 was detected by Western blot and immunohistochemistry in adenocarcinoma of colon tissues and corresponding adjacent normal tissues.[Results] Positive rate of annexin A5 in adenocarcinoma of colon tissues was significantly higher than that in corresponding adjacent normal tissues（P0.05）.Furthermore,expression of annexin A5 correlated with tumor size and lymph node metastasis（P0.05）.[Conclusion] Annexin A5 plays an important role in the carcinogensis and metastasis of colon adenocarcinoma,and it may be a new target of clinical therapy for adenocarcinoma of colon.