补气养阴解郁茶抗抑郁作用研究

Study on Antidepressant-like Effects of Buqi Yangyin Jieyu tean

目的考察补气养阴解郁茶(由山药∶大枣∶枸杞子∶玫瑰花∶绞股蓝=1∶1∶1∶1∶1组成)的抗抑郁作用。方法采用昆明(KM)雄性小鼠,每组10只。补气养阴解郁茶(Tean)及阳性药盐酸氟西汀(FH)均以0.5%CMC-Na溶解或混悬至所需给药浓度,Tean剂量5,10,20 g/kg,FH剂量10 mg/kg,模型组给予同等体积的0.5%CMC-Na,各组均连续灌胃(ig)给药7天,1次/d,末次给药1 h后,开展小鼠悬尾实验(TST)、强迫游泳实验(FST)和开场实验(OFT)测试。结果 Tean(5,10,20 g/kg)可使小鼠在TST及FST的不动时间均显著性缩短(P<0.05),且呈现出良好的量效关系;各组小鼠OFT穿格次数比较,均无显著性差异(P>0.05)。结论首次证实补气养阴解郁茶具有抗抑郁作用。

Objective To investigate the antidepressant-like effects of Buqi Yangyin Jieyu tean（Tean） for the first time. MethodsMice were treated with doses of Tean and fluoxetine hydrochloride（FH） as positive drug everyday for seven consecutive days by intragastric administration（ig）.The mouse forced swim test（FST）,tail suspension test（TST） and open field test（OFT） were used to observe antidepressant-like effects of Tean at 1 h after the last administration. ResultsCompared with the model group（CMC-Na）,Tean（5,10,20 g/kg） significantly reduced the immobility time in dose-dependent manners during the FST and the TST. ConclusionTean exerts antidepressant-like effect.