不同剂量泮托拉唑治疗溃疡性结肠炎并下消化道出血的疗效观察

Therapeutic Efficacy Observation on Different doses of Pantoprazole for Ulcerative Colitis with Lower Diges- tive Tract Bleeding

为观察不同剂量泮托拉唑静脉注射治疗溃疡性结肠炎并下消化道出血的疗效，将76例溃疡性结肠炎并下消化道出血患者分为低剂量组（37例）和大剂量组（39例）。低剂量组静脉注射泮托拉唑40mg，大剂量组静脉注射泮托拉唑80mg，疗程均为10d。分别统计两组总有效率并测定两组患者治疗前后血清IL-6、IL-8的水平。结果显示，大剂量组患者疗效（74．4％）明显优于低剂量组（56．8％），两组总有效率比较有显著性差异（P〈0．05）；治疗后，大剂量组患者临床疾病活动指数（DAI）较低剂量组明显降低（P〈0．05）；大剂量组慢性下消化道出血治疗总有效率明显高于低剂量组（P〈0．05）。低剂量组和大剂量组均可使患者治疗后IL-6和IL-8水平降低，差异有统计学意义（P〈0．05），但大剂量组效果更加明显。两组患者均未出现严重不良反应。结果表明，大剂量应用泮托拉唑静脉注射对溃疡性结肠炎并下消化道出血疗效满意。

In order to observe the clinical efficacy of different doses of pantoprazole for ulcerative colitis with lower digestive tract bleeding, 76 cases of this disease were divided into low-dose group（ n=37） and large-dose group（ n = 39）. Low-dose group received pantoprazole in a dose of 40rag and large-dose group in a dose of 80 rag. Both groups were treated for 10 days and then were compared for total effective rate and were determined for the serum level of IL-6 and IL-8. As results,the efficacy in large-dose group was obvi- ously superior to low-dose group （74.4% vs 56.8%） and the total effective rate of the two groups showed significant difference（ P 〈0.05）. After treatment, the DAI （disease activity index） decreased obviously in large-dose group than in low-dose group（ P〈0.05）. The total effective rate was obviously higher in large- dose group than in low-dose group（ P〈0.05）. The serum level of IL-6 and IL-8 decreased in both groups after treatment but more obviously in large-dose group,which showed significant difference （ P〈0.05）. No serious adverse reactions occurred in both groups. It is concluded that ulcerative colitis with lower di- gestive tract bleeding can be satisfactorily controlled by large-dose of pantoprazole.