期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Fluorescence quenching of triazatruxene-based glycocluster induced by peanut agglutinin lectin

Fluorescence quenching of triazatruxene-based glycocluster induced by peanut agglutinin lectin
原文传递
导出
摘要 A novel triazatruxene-based fluorescent glycocluster was synthesized and its selective binding interactions with PNA lectin were investigated by fluorescence spectroscopy,CD spectroscopy,and a turbidity assay.The glycocluster exhibited a strong binding affinity for PNA lectin with a Stern-Volmer quenching constant of 5.8×10^5 mol^-1L A novel triazatruxene-based fluorescent glycocluster was synthesized and its selective binding interactions with PNA lectin were investigated by fluorescence spectroscopy,CD spectroscopy,and a turbidity assay.The glycocluster exhibited a strong binding affinity for PNA lectin with a Stern-Volmer quenching constant of 5.8×10^5 mol^-1L
作者 Ke-Rang Wang Hong-Wei An Dan Han Feng Qian Xiao-Liu Li
机构地区 Key Laboratory of Chemical Biology of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第6期467-470,共4页 中国化学快报（英文版）
基金 supported by the National Natural Science Foundation of China(Nos.21002020 and 21172051) the Hebei Natural Science Foundation(Nos.B2011201052 and B2012201041)
关键词 Triazatruxene Glycocluster Fluorescence quenching Peanut agglutinin Triazatruxene Glycocluster Fluorescence quenching Peanut agglutinin
分类号 O621.3 [理学—有机化学]
  • 相关文献

参考文献28

  • 1D.H. Dube, C.R. Bertozzi, Glycans in cancer and inflammation-potential for thera- peutics and diagnostics, Nat. Rev. Drug Discov. 4 (2005) 477-488.
  • 2P.M. Rudd, T. Elliott, P. Cresswell, I.A. Wilson, R.A. Dwek, Glycosylation and the immune system, Science 291 (2001) 2370-2376.
  • 3A. Bernardi, J. Jimenez-Barbero, A. Casnati, et al., Multivalent glycoconjugates as anti-pathogenic agents, Chem. Soc. Rev. (2013), http://dx.doi.org/10.10391 c2cs35408j.
  • 4J.J. Lundquist, E.J. Toone, The cluster glycoside effect, Chem. Rev. 102 (2002) 555-578.
  • 5M. Mammen, S.K. Choi, G.M. Whitesides, Polyvalent interactions in biological systems: implications for design and use of moltivalent ligands and inhibitors, Angew. Chem. Int. Ed. 37 (1998) 2754-2794.
  • 6R.J. Pieters, Maximising multivalency effects in protein-carbohydrate interac- tions, Org. Biomol. Chem. 7 (2009) 2013-2025.
  • 7M. Hartmann, T.K. Lindhorst, The bacterial lectin FimH, a target for drug discov- ery-carbohydrate inhibitors of type I fimbriae-mediated bacterial adhesion, EurJ. Org. Chem. (2011) 3583-3609.
  • 8D. Deniaud, K. Julienne, S.G. Gouin, Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands, Org. Biomol. Chem. 9 (2011) 966-979.
  • 9K. Petkau, A. Kaeser, 1. Fischer, L. Brunsveld, A.P.H.J. Schenning, Pre- and post- functionalized self-assembled "rr-conjugated fluorescent organic nanoparticles for dual targeting, J. Am. Chem. Soc. 133 (2011) 17063-17071.
  • 10G.T. Noble, S.L Flitsch, K.P. Liem, S.J. Webb, Assessing the cluster glycoside effect during the binding of concanavalin A to mannosylated artificial lipid rafts, Org. Biomol. Chem. 7 (2009) 5245-5254.
Chinese Chemical Letters
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部