凝血纤溶指标在卵巢过度刺激综合征中的临床应用分析

Clinical application of coagulation fibrinolysis index in patient with ovarian hyperstimulation syndrome

目的探讨凝血纤溶指标在卵巢过度刺激综合征(OHSS)患者中的改变,为临床治疗提供依据。方法选取64例接受体外受精-胚胎移植(IVF-ET)治疗后发生OHSS患者和40例同期治疗未发生OHSS患者作为对照,收集血浆检测血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体水平,采用t检验分析OHSS患者与对照者凝血纤溶指标的差异,以及治疗前后血浆FIB和D-二聚体活性差异。结果 OHSS患者与对照组比较,PT和TT时间延长,APTT时间缩短,均在正常参考范围内。FIB和D-二聚体含量增高,与对照组比较差异有统计学意义(P<0.05)。OHSS患者治疗后血浆FIB和D-二聚体水平较治疗前下降,差异有统计学意义(P<0.05)。结论血浆凝血纤溶指标用于评估OHSS患者的凝血功能,为临床治疗及预后判断提供重要依据。

Objective To investigate coagulation fibrinolysis index in the patients with ovarian hyperstimulation syndrome（OHSS）,and to explore the clinical value.Methods 64 patients undergoing invitro fertilization and embryo transferb（IVF-ET） were developed OHSS and 40 patients as control group who didn′t undergoing OHSS in the same period were analyzed.Plasma samples were collected,and the levels of plasma PT,APTT,TT,FIB and D-dimer were measured and analyzed by t test.Results Compared with control group,PT and TT were longer,but APTT was shorten.Their levels were lied in the reference limit.The levels of FIB and D-dimer of the OHSS patients were higher than control group（P＆lt;0.05）,but their levels were decreased after the treatment（P＆lt;0.05）.Conclusion Evaluation of the blood coagulation and fibrinolysis function may be important for predicting prognosis and therapeutic effect for OHSS patients.