1503例9种呼吸道感染病原体检测结果分析

Analysis of 9 kinds of respiratory tract infection pathogens in 1503 cases

目的探讨婴幼儿呼吸道感染的病原体流行情况。方法采用间接免疫荧光法(IFA)检测1 503例住院婴幼儿患者血清中嗜肺军团菌血清Ⅰ型、肺炎支原体、Q热立克次体、肺炎衣原体、腺病毒、呼吸道合胞病毒、甲型流感病毒、乙型流感病毒和副流感病毒1、2和3型等9种呼吸道感染病原体的IgM抗体。结果在1 503例样本中,共检测出IgM抗体阳性病例499例,阳性检出率为33.20%,其中肺炎支原体387例(25.75%),肺炎支原体合并呼吸道合胞病毒5例(0.33%),肺炎支原体合并腺病毒4例(0.27%),单纯呼吸道合胞病毒34例(2.26%),副流感病毒1、2和3型30例(2.00%),单纯腺病毒19例(1.26%)、乙型流感病毒13例(0.86%)和甲型流感病毒7例(0.47%),未检出Q热立克次体、肺炎衣原体、嗜肺军团菌血清Ⅰ型。结论采用间接免疫荧光法快速检测人血清中9种呼吸道感染主要病原体的IgM抗体,可为临床的诊断和治疗提供重要的参考依据,避免抗生素的滥用。

Objective To investigate the epidemic situation of infants with respiratory tract infection pathogens.Methods IgM antibodies in serum of Legionella pneumophila serogroup 1,Mycoplasma pneumoniae,Chlamydia pneumoniae,Q Rickettsia,adenovirus,respiratory syncytial virus,influenza A virus,influenza B virus,Parainfluenza virus 1,2 and 3 were detected by indirect immunofluorescence（IFA） in 1 503 Infant patients.Results There were 499 positive cases in the 1 503 infant patients,the positive rate was 33.20%.In which,387 cases were mycoplasma pneumonia（25.75%）,5 cases were mycoplasma pneumonia merger respiratory syncytial virus（0.33%）,4 cases were mycoplasma pneumonia merger adenovirus（0.27%）,34 cases were respiratory syncytial virus（2.26%）,30 cases were parainfluenza virus 1,2 and 3,19 cases were simple adenovirus（1.26%）,13 cases were influenza B virus（0.86%）,7 cases were influenza A virus（0.47%）,and there were no Q Rickettsia,Chlamydia pneumoniae,Legionella pneumophila serogroup 1.Conclusion The detection of serum IgM antibody of nine kinds of main pathogens of respiratory tract infection by indirect immunofluorescence（IFA）,can provide the important reference frame for clinical diagnosis and treatment,and to avoid the abuse of antibiotics.