氟喹诺酮类药物的药理特点

Pharmacological characteristics of fluoroquinolones

作为三、四代喹诺酮药物中的氟喹诺酮,因其本身的结构多了一种氟元素,因此使得该药物在药代动力学,临床使用方面以及疗效价格比等方面都取得长足的进步。近几年来,随着β-内酰胺类和氨基糖甙类药物的耐药菌株的不断增加,使得医院在临床工作中开始重视氟喹诺酮类药物。为了能够充分了解氟喹诺酮类药的药理特点,该文将从抗菌活性的广泛性、新奇的抗菌作用机制、氟喹诺酮类药的耐药机制及药物代谢的特点等方面逐一进行阐述。

：Fluoroquinolone is the third and forth generation quinolone drug, which the structure has the additional element of fluo- rine, so it presents great advantages in pharmaeokinetics, clinical application and effect price ratio as compared with other drugs. In recent years, because the 13-1actam and aminoglycosides resistance strains have increased ceaselessly, the doctors are starting to pay attention to fluoroquinolones in clinical work. In order to fully understand the pharmacological characteristics of fluoroquinolones, this paper elaborates the extensive antibacterial activity, novel antibacterial mechanism, resistance mechanism of fluoroquinolones and characteristic of drug metabolism.