异麦芽酮糖醇急性和亚慢性毒性研究

Study on acute and sub-chronic toxicity of Isomalt

目的:研究异麦芽酮糖醇急性和亚慢性毒性。方法:采用小鼠急性经口毒性试验和大鼠90天喂养试验进行检测。结果:异麦芽酮糖醇对小鼠的急性经口LD50>20 000 mg/kg.BW,属无毒级;大鼠90天喂养试验各项检测结果均未见异常,未见大鼠器官组织病理学改变,未观察到有害作用剂量(NOAEL)大于8 000mg/kg.BW。结论:异麦芽酮糖醇在本实验条件下未见有急性和亚慢性毒性。

Objective：To study the acute and sub-chronic toxicity of Isomalt.Methods：Mouse acute oral toxicity te-st and 90-day feeding test were used to assess the toxicity of Isomalt..Results：The oral LD50 of Isomalt in mice was more than 20 000 mg/kg.BW,which belonged to an actual non-toxicity substance.There were no significant differences in all test items compared with the control group,and no histopathological changes were observed in rats in 90-day feeding test,the No-observed-adverse-effect-level（NOAEL） on rats is 8 000 mg/kg.BW.Conclusion：Under the present condition,Isomalt was nontoxic neither on acute toxicity nor on sub-chronic toxicity.