红细胞免疫粘附活性、补体受体在良性妇科疾病行腹腔镜手术治疗患者中的变化

Changes of erythrocyte immune adherence activity and CD35 in patients with benign gynecological disorders undergone laparoscopic surgery

目的:探讨良性妇科疾病患者行腹腔镜手术后红细胞粘附活性以及红细胞补体受体的变化。方法:良性妇科疾病患者64例随机分为研究组和对照组,分别采用腹腔镜治疗和开腹手术治疗。检测两组CD35、RBC-C3bRR、RBC-ICR以及其他免疫指标。结果:两组CD35、RBC-ICR术前及术后、组内及组间比较差异均无统计学意义(P>0.05)。RBC-C3bRR两组术后24 h均有下降,但对照组下降更明显,与术前24 h比较,差异有统计学意义(P<0.01),术后72 h两组组间比较,差异有统计学意义(P<0.01)。两组术后24h外周血白细胞、IL-6、TNF-α均明显升高(P<0.01),但外周血白细胞、IL-6对照组较研究组升高幅度更大(P<0.01)。结论:腹腔镜手术对良性妇科疾病患者红细胞免疫粘附活性、补体受体的影响弱于开腹手术。

Objective： To discuss changes of erythrocyte immune adherence activity and CD35 in patients with benign gynecological disorders undergone laparoscopic surgery.Methods： Sixty-four cases with benign gynecological disorders were devided into study group（34 cases） and control group（30 cases）.Erythrocyte immune adherence activity,red blood cell complement receptor,inflammatory cytokines,peripheral white blood cell of the two groups were detected.Results： CD35 and RBC-ICR had no dignificant difference between before and after therapy and two groups（P＆gt;0.05）.RBC-C3bR decreased apparently after 24h after operation in two groups,and control group decreased more compared to that before surgery（P＆lt;0.01）.RBC-C3bRR had significant difference between two groups 72h after surgery（P＆lt;0.01）.Peripheral white blood cell,IL-6 increased apparently 24h after surgery in two groups（P＆lt;0.01）,and control group increased more（P＆lt;0.01）.TNF-αincreased apparently 24h after surgery in two groups（P＆lt;0.01）.Conclusion： Laparoscopic surgery has less impact on erythrocyte immune adherence activity and CD35 in patients with benign gynecological disorders than open surgery.