150例异位妊娠药物保守治疗效果和影响因素分析

The effectiveness and impact factors on conservative drug treatment for 150 cases ectopic pregnancy

目的探讨影响异位妊娠保守治疗效果的相关因素，为保守治疗提供依据。方法选择2010-2012年本院应用药物保守治疗的异位妊娠患者150例。其中成功组107例，失败组43例。比较β-HCG、子宫内膜厚度、包块直径及盆腔积液量等指标。结果失败组β-HCG为（3465．2±305．1）IU／L，高于成功组（2684．3±284．7）IU／L，差异有统计学意义（t=14．88，P〈0．01）；失败组包块直径为（3．15±0．40）cm，大于成功组直径（2．47±0．38）cm，差异有统计学意义（t=9．76，P〈0．01）；失败组腹痛时间（6．04±0．81）d，比成功组腹痛时间（2．47±0．38）d长（t=6．02，P〈0．01）；失败组宫内膜厚度大干成功组（t=9．95，P〈0．01）；logistic分析，血清β-HCG、包块大小和宫内膜厚度与保守治疗成功差异具有显著性（P〈0．05）。结论不同的血β-HCG水平、B超包块直径及内膜厚度与异位妊娠保守治疗的成功率有一定的关联性。

Objective To explore the related influence factors on conservative treatment for ectopic pregnancy, and provide the basis for conservative treatment. Methods From January 2010 to December 2012, 150 ectopic pregnancy patients with conservative medical treatment, Which including of 107 cases in successful group, 43 cases in failure group. Compared beta- HCG, endometrial thickness, mass diameter, and pelvic fluid volume indicators. Results β-HCG of failure group was （3 465.18 ±305.06） IU / L, which was higher than the successful group （2 684.35 ±284.74）IU/L, the difference was statistically significant （ t= 14. 88 ,P〈0.05 ） ; The mass diameter of failure group（3.15±0.40） cm was more than that of the successful group （2.47 ±0.38 ）cm, the differences was significant （t = 9. 76, P〈0.05 ） ; The abdominal pain time of the failure group （6. 04 ±0.81 ） d was longer than that of the successful group （2.47 ± 0. 38） d （ t = 6. 02, P〈 0.01 ） ; The endometrial thickness of failure group was greater than that of the successful group （ t = 9. 95, P〈 0.01 ） ; By logisticanalysis, There were significant difference among serum β-HCG, mass size and endometriahhickness with conservative treatment （P〈0.05）. Conclusion The success rate of conservative treatment for ectopic pregnancy were certain relevance with blood level of β-HCG, mass diameterand endometrial thickness.