结核分枝杆菌药物敏感性表型检测的研究进展

Research progress of phenotype detection of M y cobacterium tuberculosis drug susceptibility

全球耐药结核病疫情依旧严峻,我国尤甚,结核分枝杆菌药物敏感性表型检测在耐药结核病的诊断中仍占有重要地位,本综述论述了近年来多种表型药敏检测方法及国内外研究进展,讨论汇总了各种药敏试验方法的敏感度、特异度及各方法的优缺点,为临床及实验室根据不同需求选择药敏方法提供依据。

The epidemic situation of global drug-resistant tuberculosis is still severe,particularly in China.The phenotype detection of Mycobacterium tuberculosis drug susceptibility still plays an important role in the diagnosis of drug-resistant tuberculosis.This paper discussed the research progress of various phenotypic drug susceptibility testing methods at home and abroad in recent years,summarized the sensitivities,specificities of various methods and their advantages and disadvantages,which will provide a basis for selecting drug susceptibility test methods in clinical laboratories according to the different demand.