紫椴花抗炎镇痛作用有效部位的研究

Anti-inflammatory and Antinociceptive Effective Parts of Tiliaamurensis Rupr.Inflorescences

目的:研究紫椴花抗炎和镇痛作用的有效部位。方法:采用二甲苯致小鼠耳肿胀模型、纸片肉芽肿模型和醋酸扭体法。结果:紫椴花正丁醇部位和水部位(2.26g/kg)对二甲苯引起的小鼠耳肿胀具有显著的抑制作用(P<0.01),其肿胀抑制率均大于50%;紫椴花正丁醇部位对纸片引起的小鼠肉芽增生具有显著的抑制作用(P<0.05);紫椴花正丁醇部位对醋酸引起的小鼠疼痛具有显著的抑制作用(P<0.01);紫椴花正丁醇部位对小鼠疼痛潜伏期较长(P<0.01)。结论:紫椴花抗炎镇痛的有效部位为正丁醇部位。

Objective ： To determine the anti - inflammatory and antinociceptive effective parts of T. amurensisin florescences. Method：Dimethylbenzene- induced mouse ear edema experiment and the chronic inflammatory reaction of paper induced rat granuloma were performed to study the antiinflammatory effects. The analgesic action was observed by using the mouse acetic acid writhing test. Results ： Effective parts of n - butanol extracts of T. amurensis inflorescences could significantly inhibit the dimethylbenzene - induced mouse ear edema （P 〈 0.01 ） , the writhing response induced by acetic acid （P 〈 0.05 ） and the chronic inflammatory reaction of paper induced rat granuloma（ P 〈 0.01 ）. The incubation period was longer with a significant difference from those of controls（P 〈 0.01 ）. Conclusion： The anti -inflammatory and antinociceptive effective parts of T. amurensis inflorescences are n- butanol extracts.