阿奇霉素联合阴道抑菌凝胶治疗女性生殖道解脲支原体感染的临床观察

Clinical observation of azithromycin combined vaginal antibacterial gel on female genital tract mycoplasma infection

目的观察阿奇霉素联合阴道抑菌凝胶治疗女性生殖道解脲支原体感染的临床疗效。方法选择牡丹江医学院附属第二医院妇科门诊生殖道解脲支原体感染者120例,随机分为治疗组(70例)和对照组(50例),对照组患者第一天服用阿奇霉素1g/次,1次/d,中间不用药,3d后0.5g/次,1次/d,连服5d,共治疗9d。治疗组患者每晚睡前清洗外阴后,将阴道抑菌凝胶推入阴道深部,每晚1支,连用9d(如遇经期停用),阿奇霉素的用法及用量同对照组;两组患者停药5d后来医院复查,做解脲支原体培养,结合临床症状、体征判断疗效。结果治疗后,治疗组和对照组的显效率分别为84.3%、54.0%,两组比较差异具有显著性(P<0.05)。治疗组中有2例(2.86%)患者阴道上药后出现阴道灼热感,外阴皮肤瘙痒,停药后消失;对照组3例(6%)服药后出现腹泻、恶心等胃肠道反应,停药后自然好转。结论阿奇霉素联合阴道抑菌凝胶治疗女性生殖道解脲支原体感染具有较好疗效,且使用方便,不良反应少,值得临床推广。

Objective To observe the effect of azithromycin combined with vaginal antibacterial gel in the treatment of female genital tract mycoplasma infection in clinic.Methods Patients（120 cases）who were infected with genital tract mycoplasma in Out-patient Gynecological Department,Second Affiliated Hospital of Mudanjiang Medical College,were randomly divided into the treatment group（70 cases）and control group（50 cases）.Patients in the control group were taken azithromycin 1 g once daily for the first 1-3 d,after 3 d,0.5 g/d,once daily for 5 d,a total of 9 d.Patients in the treatment group washed the vulva before sleeping every night,then pushed vagina antibacterial gel into the vagina,once one night,for 9 d（menstrual disabled）.Usage and dosage were the same with the control group.Two groups of patients came back to the hospital when the drug was stopped 5 d later,and they did ureaplasma urealyticum.Efficacy was determined by culture results combined with clinical symptoms and signs.Results After the treatment,the significant efficiency of the treatment and control groups was 84.3% and 54.0% with significant difference（P ＆lt; 0.05）.Two cases（2.86%）in the treatment group appeared vaginal burning and genital itching,and those symptoms disappeared after stopping drugs.Three cases（6%）in the control group appeared diarrhea,nausea and other gastrointestinal reactions,which turned better after stopping drug.Conclusion Azithromycin combined with vaginal antibacterial gel in the treatment of female genital tract mycoplasma infection has a better curative effect,and the usage is convenient with less adverse reaction,which is worth the clinical promotion.