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TTF-1在非小细胞肺癌中的表达及意义 被引量：8

Expression and Clinical Significance of TTF-1 in Non-small Cell Lung Cancer
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摘要 目的探讨甲状腺转录因子-1(TTF-1)在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法采用免疫组化(SP法)对75例非小细胞肺癌(其中肺腺癌36例,肺鳞癌39例)组织中TTF-1的表达进行检测,以其正常癌旁组织作为对照,分析TTF-1在肺腺癌与鳞癌鉴别诊断中的意义,及其表达与患者临床病理特征及预后的关系。结果 TTF-1在肺腺癌中的阳性表达率为83.3%(30/36),在肺鳞癌中的阳性表达率为7.69%(3/39),差异有统计学意义(P<0.05);TTF-1的表达与患者性别、年龄、淋巴转移、肿瘤大小和肿瘤TNM分期等临床病理特征无关(P>0.05)。Kaplan-Meier分析显示,肺腺癌阳性组患者的中位生存时间为30个月,明显高于阴性组患者的中位生存时间7.5个月,差异具有统计学意义(P<0.05);肺鳞癌阳性组患者的中位生存时间为29个月,阴性组为48个月,差异无统计学意义(P>0.05)。结论检测TTF-1对非小细胞肺癌不同组织学类型的诊断、鉴别诊断具有一定的实用价值,其过高表达有可能作为肺腺癌预后良好的评估指标。 Objective To explore the expression and Clinical significance of TTF-1 in NSCLC tissues.Methods Immunohistochemistry（SP method）was used to detect the expression of TTF-1 in 75 cases of NSCLC tissues（including 36 cases of adenocarcinoma and 39 cases of squamous cell carcinoma）,with its normal carcinoma tissue adjacent to reference.The value of TTF-1 in the identification of adenocarcinoma and squamous cell carcinoma was explored.And the relationships between TTF-1 expression and clinicopathologic characteristics and prognosis in non-small cell lung cancers were analyzed.Results The positive expression rate of TTF-1 in adenocarcinoma tissues（30/36,83.3%） was significantly higher than that in squamous cell carcinoma tissues（3/39,7.69%）（P＆lt; 0.05）.And the expression of TTF-1 is unrelated to clinical and pathologic data such as patients’genders,ages,TNM stages,tumor size and lymph nodes metastasis（P＆gt;0.05）.Moreover,univariate prognostic factor analyzed by Kaplan-Meier method indicated that in the median survival time for adenocarcinoma with positively expression of TTF-1 was significantly longer than that of patients with negatively expression of TTF-1（P＆lt;0.05）.However,in squamous cell carcinoma,it doesn’t seem like it has a clearly meaning.Conclusion TTF-1 is involved in the development of lung cancer.The detection of expression of TTF-1 can be used for the diagnosis and identification of adenocarcinoma and squamous cell carcinoma.It might he a potentially valuable indicator to predict the prognosis of patients in NSCLC.
作者 蒋榕 莫晓能
机构地区 中山大学附属第六医院呼吸内科
出处 《中国实用医药》 2013年第14期4-6,共3页 China Practical Medicine
基金 广东省科技计划项目(项目编号:2010B031600227)
关键词 TTF-1 非小细胞肺癌 免疫组化 预后分析 TTF-1 NSCLC Immunohistochemistry Prognostic analysis
分类号 R734.2 [医药卫生—肿瘤]
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参考文献12

  • 1Travis WD, Colby TV, Corrin B, et al. In collaboration with Sobin LH and pathologists from 14 countries. WHO Histological Typing of Lung and Pleura Turnouts. 3rd ed. Berlin: Springer,1999.
  • 2Travis WD. Pathology of Lung Cancer. Clin Chest Med, 2002, 23 : 65-81.
  • 3高宗炜,郭春宝,金先庆.人肺癌中甲状腺转录因子-1DNA结合活性的意义[J].中国肺癌杂志,2009,12(2):127-130. 被引量：8
  • 4Mendelson C IL Role of transcription factors in fetal lung develop- mentand surfactant protein gene expression. Annual Review of Physi- ology, 2000,62:875-915.
  • 5MyongNH. Thyroid transcription facter-1 ("l'rF-1) expression in human lung carcinomas:its prognostic implication and relation ship with expressions of p53 and Ki-57 proteins. Journal Of Korean Medi- cal Science ,2003,18 (4) :494-500.
  • 6Travis W D, Colby T V, Corrin B, et 81. WHO Histological typing of lung and pleural tumors. 3rd ed, Berlin: Springer, 1999:35.
  • 7韩高华,周晓军,孟奎,陆珍凤.TTF-1在肺腺癌中的表达及其诊断意义[J].临床与实验病理学杂志,2002,18(6):595-597. 被引量：21
  • 8Wang BY, Gil J, Kaufman D. p63 in pulmonary epithelium, pul- monaey squamous neoplasms, and other pulmonary tumors. Human Pathology,2002, 33(9) : 921-926.
  • 9Yang A, Kaghad M, Wang Y. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Molecular Cell, 1998, 2 ( 3 ) : 305-316.
  • 10Altaner S, Yoruk Y, Tokatli F, et al. The correlation between TTF-1 immunoreactivity and the occurrence of lymph node metas- tases in patients with lung cancer. Tumori, 2006, 92 (4):323-326.

二级参考文献19

  • 1Schmitt R, Weichert W. Immunostaining of small-cell carcinoma: mistaken identity? Lancet, 2003, 362(9395): 1583.
  • 2Gomez-Fernandez C, Jorda M, Delgado PI, et al. Thyroid transcription factor 1: a marker for lung adenoarinoma in body cavity fluids. Cancer, 2002, 96(5): 289-293.
  • 3Li C, Zhu NL, Tan RC, et al. Transforming growth faetor-β inhibits pulmonary surfaetant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription faetors. J Biol Chem, 2002, 277(41): 38399-38408.
  • 4Tan D, Li Q, Deeb G, et al. Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study. Hum Pathol, 2003, 34(6): 597-604.
  • 5Rossi G, Cavazza A, Sturm N, et aI. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol, 2003, 27(3): 311-324.
  • 6Fujita J, Ohtsuki Y, Bandoh S, et al. Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines. Lung Cancer, 2003, 39(1): 31-36.
  • 7Zamecnik J, Kodet R. Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch, 2002, 440(4): 353-361.
  • 8Wu M, Wang B, Gil J, et al. p63 and TTF-1 immunostaining. A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of lung. Am J Clin Pathol, 2003, 119(5): 696-702.
  • 9Ng WK, Chow JC, Ng PK. Thyroid transcription factor-1 is highly sensitive and specific in differentiating metastatic pulmonary from extrapulmonary adenocarcinoma in effusion fluid cytology specimens. Cancer, 2002, 96(1): 43-48.
  • 10Travis WD, Colby TV, Corrin B et al. (WHO) Histological typing of lung and pleural tumors. 3rd ed, Berlin:Springer, 1999:35

共引文献25

同被引文献72

  • 1林冬梅,邹霜梅,吕宁,温芃,刘秀云,何祖根.甲状腺转录因子1在肺癌中的表达及应用[J].中华肿瘤杂志,2004,26(10):615-617. 被引量：12
  • 2刘翼军,王春福.P63和TTF-1在肺小细胞癌与低分化鳞癌中的鉴别诊断价值[J].江西医药,2005,40(3):170-171. 被引量：2
  • 3陆鸣,董亚文,王翠芝,陈书媛,韦萍,刘金香.TTF-1在肺腺癌中的表达特点及意义[J].诊断病理学杂志,2007,14(5):353-356. 被引量：5
  • 4Mukhopadhyay S,Katzenstein A L.Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens:Utility of an immunohistochemical panel containing TTF-1,napsin A,p63,and CK5/6[J].Am J Surg Pathol,2011,35(1):15-25.
  • 5Ordónez N G.Thyroid transcription factor-1 is not expressed in squamous cell carcinomas of the lung:an immunohistochemical study with review of the literature[J].Appl Immunohistochem Mol Morphol,2012,20(6):525-530.
  • 6Emiko Aikawa , CT; Akihiko Kawahara, PhD ; atoshl Hatton, PhD etc. Comparision of the Expression Levels of Napsin A, Thyroid TranscriptionFactor - 1, and p63in Nonsmall Cell Lung Cancer Using Cytoeentrifuged Bronchial Brushings [ J ]. Cancer ( Cancer Cytopathol) , 2011,119 : 335 - 345.
  • 7Loo PS, Thomas SC, Nicolson MC, et al. Subtypiug of undifferentiated non-small cell carcinomas in bronchial biopsy specimens [ J ]. J Thorac Oncol, 2010,5 (4) :442 - 447.
  • 8Pelosi G, Rossi G, Bianchi F, et al. Immunohistochemistry by Means of Widely Agreed-Upon Markers ( Cytokeratins5/6 and 7, p63, Thyroid Transcription Factor - 1, and Vimentin) on Small Biopsies of Non-small Cell Lung Cancer Effectively Parallels the Corresponding Profiling and Eventual Diagnoses on Surgical Specimens[J]. Thorac Oneol, 2011, 6(6): 1039-1049.
  • 9Rekhtman N, Ang DC, Sima CS, et al. Immunohistochemieal algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens [J]. Mod Pathol, 2011, 24 (10) : 1348 - 1359.
  • 10Zhang C, Schmidt LA, Hatanaka K, et al. Evaluation of napsin A, TTF-1, 1o63, p40, and CK_5/6 pulmonary neuroendocrine tumors [ J ]. Am J Clin Pathol, 2014 , 142 ( 3 ) : 320 - 324.

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中国实用医药
2013年 第14期

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