瘦素受体在乳腺癌组织中的表达及其与临床预后的关系

The expression of leptin receptor in breast cancer and the relationship with clinical prognosis

目的检测瘦素受体(ObR)在人乳腺癌组织中的表达情况,探讨其与HER-2以及临床病理之间的关系,并分析它们对预后的影响。方法用免疫组织化学的方法检测124例乳腺癌组织中ObR的表达,回顾分析相关的临床病理资料和随访情况。结果 ObR在大多数乳腺癌组织中均有表达,阳性率为82.3%。ObR表达与患者的年龄、绝经状态、肿瘤大小、肿瘤病理学分型、淋巴结转移均无关(P>0.05);与ER、PR、P53的表达状态也无关(P>0.05);ObR的表达与HER-2相关(P=0.011);ObR阳性者与阴性者的总生存率检验(χ2=0.048,P=0.827)及无病生存率检验(χ2=2.829,P=0.093)差异均无统计学意义。结论 ObR与HER-2在乳腺癌中的表达具有相关性,可能是导致乳腺癌预后不良的因素。

Objective To detect clinicopathologic factors and prognosis of leptin receptor（ObR） expression in breast cancer tissue,and to investigate the relationship between HER-2 as well as the clinical and pathological,and analyze their impact on prognosis.Methods By using immunohistochemistry method to detect the ObR in 124 cases of breast cancer expression related to clinical and pathological data and follow-up were analyzed retrospectively.Results ObR were expressed in most breast cancer tissues,the positive rate was 82.3%.ObR expression had no relationship with the age of patients,the transfer of menopausal status,tumor size,histological type,lymph node（P＆gt;0.05）,it had nothing to do with the expression of ER,PR,P53（P＆gt;0.05）,the expression of ObR was correlated with HER-2（P=0.011）;between the survival rate test of patients with positive ObR and negative ObR（χ2=0.048,P=0.827） and disease free survival rate test（χ2=2.829,P=0.093）,there were no significant differences.Conclusion The expression of ObR and HER-2 were associated in breast cancer,may be the factors that lead to poor prognosis of breast cancer.